IMPORTANCE OF CATALASE ENZYME IN VIRULENCE OF ISONIAZID RESISTANT ST RAINS OF MYCOBACTERIUM TUBERCULOSIS IN GUINEAPIGS
نویسندگان
چکیده مقاله:
In this study, twenty-five strains of Mycobacterium tuberculosis resistant to isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ]. The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains resistant to INH as well as virulent to guinea-pigs, eight of them were found to be catalase positive and only one strain was catalase negative, whereas the remaining sixteen INH resistant strains were catalase negative. A strong association was observed between INH resistance and catalase positivity and virulence (p<0.0001 chi-square test). This study supports the hypothesis that catalase has an important role in the virulence of INH-resistant strains of M tuberculosis.
منابع مشابه
importance of catalase enzyme in virulence of isoniazid resistant st rains of mycobacterium tuberculosis in guineapigs
in this study, twenty-five strains of mycobacterium tuberculosis resistant to isoniazid (inh) were isolated from patients with tuberculosis (tb). nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (riv» 1 ]. the remaining sixteen strains (64%) were non-virulent (riv <1). of the nine strains resistant to inh as well as virulent to guinea-pigs, eight of them were fo...
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عنوان ژورنال
دوره 14 شماره 3
صفحات 293- 295
تاریخ انتشار 2000-11
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